Description

Fmoc-n-Lys-(Dpeg-Biotin)-Oh-(Acid) CAS NO 1334172-65-4 is a specialized, high-purity protected amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound is engineered to provide a cleavable linker system, integrating an Fmoc-protected lysine residue with a biotin tag via a discrete polyethylene glycol (dPEG®) spacer, enabling precise biomolecular labeling and purification. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation, where controlled biotinylation and subsequent affinity capture are critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the site-specific incorporation of biotin handles into synthetic peptides.
• Affinity Probe Development: Creation of biotinylated ligands, antibodies, or proteins for pull-down assays, ELISA, and Western blotting.
• Drug Discovery & Target Identification: Synthesis of biotin-conjugated small molecules or peptides for target fishing and validation studies using streptavidin-based platforms.
• Diagnostic Reagent Manufacturing: Production of key intermediates for in-vitro diagnostic (IVD) kits requiring stable, linker-mediated biotin attachment.
• Biomaterial Surface Functionalization: Modification of surfaces (e.g., chips, beads) with biotin for biosensor and microarray applications.
• ADC (Antibody-Drug Conjugate) Research: Exploration of novel linker-payload constructs in bioconjugation strategies.

Basic Information

Product Name	Fmoc-n-Lys-(Dpeg-Biotin)-Oh-(Acid)
CAS No.	1334172-65-4
Molecular Formula	C₄₈H₇₀N₆O₁₂S
Molecular Weight	955.17 g/mol
Synonyms	Fmoc-Lys(dPEG®-Biotin)-OH; N-α-Fmoc-N-ε-(dPEG®-Biotin)-L-lysine; Fmoc-Lys(Biotin-dPEG®)-OH; Fmoc-Lys(Biotin-PEG)-OH; (2S)-6-[2-[2-[2-[5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-L-Lys(dPEG-Biotin)-OH; Biotin-dPEG®-Fmoc-Lys-OH; Fmoc-Protected Biotinylated Lysine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Lys-(Dpeg-Biotin)-Oh-(Acid) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to support regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.