Description

Fmoc-Lys (Biotin-Peg4)-Oh CAS NO 1334172-64-3 is a sophisticated, multifunctional amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound is engineered to provide a versatile linker system, incorporating an Fmoc-protected lysine residue, a biotin affinity tag, and a tetraethylene glycol (PEG4) spacer for enhanced solubility and reduced steric hindrance. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation, enabling the precise attachment of biomolecules to solid supports or detection systems.

Application

• Solid-Phase Peptide Synthesis (SPPS): Key building block for introducing biotinylation sites and long, flexible PEG linkers into custom peptide sequences.
• Biotin-Avidin/Streptavidin Technology: Used to label peptides, proteins, or other molecules with biotin for high-affinity capture, purification, or detection in assay systems like ELISA.
• Drug Discovery & ADC Development: Facilitates the construction of linker-payload systems in antibody-drug conjugates (ADCs) and targeted therapeutics.
• Proteomics & Biomarker Research: Enables the site-specific biotinylation of proteins for pull-down assays, protein interaction studies, and mass spectrometry analysis.
• Diagnostic Kit Manufacturing: A critical raw material for developing sensitive and specific diagnostic tests and biosensors.
• Surface Functionalization: Used to create biotinylated surfaces on chips, beads, or plates for microarray and lab-on-a-chip applications.

Basic Information

Item	Detail
Product Name	Fmoc-Lys (Biotin-Peg4)-Oh
CAS No.	1334172-64-3
Molecular Formula	C48H70N6O13S
Molecular Weight	971.16 g/mol
Synonyms	Fmoc-Lys(biotin-PEG4)-OH; Nα-Fmoc-Nε-(biotin-PEG4)-L-lysine; Fmoc-Lys(Biotin-PEG4)-OH; Fmoc-L-lysine(biotin-PEG4); Biotin-PEG4-Fmoc-Lys-OH; (2S)-6-[2-[2-[2-[2-(5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino)ethoxy]ethoxy]ethoxy]ethoxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Lys (Biotin-Peg4)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for critical research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.