Description

4-(Aminomethyl)-2-Fluorophenol Hydrochloride is a specialized fluorinated aromatic building block with a phenol and primary amine hydrochloride functional group. This compound is valued for its dual reactivity, serving as a versatile intermediate in the synthesis of complex molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of specialty polymers, dyes, and advanced organic electronic materials where fluorinated aromatic structures are required.
• Bioconjugation and Probe Synthesis: The amine hydrochloride and phenol groups make it suitable for constructing fluorescent probes, biomarkers, and antibody-drug conjugate (ADC) linkers.

Basic Information

Product Name	4-(Aminomethyl)-2-Fluorophenol Hydrochloride
CAS No.	1333560-37-4
Molecular Formula	C7H9ClFNO
Molecular Weight	177.60 g/mol
Synonyms	2-Fluoro-4-(aminomethyl)phenol hydrochloride; 4-(Aminomethyl)-2-fluorophenol HCl; (4-Hydroxy-3-fluorophenyl)methanamine hydrochloride; 2-Fluoro-4-(aminomethyl)phenol monohydrochloride; 3-Fluoro-4-hydroxybenzylamine hydrochloride; 4-(Aminomethyl)-2-fluorophenol, hydrochloride; 4-Hydroxy-3-fluorobenzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-2-Fluorophenol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.