Description

5-Chloro-2,3-Difluoroisonicotinaldehyde is a high-value, multi-functional heterocyclic building block. This compound matters as a critical intermediate for synthesizing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogenated pyridine core enables precise structural modifications. It is primarily needed by R&D chemists and process development teams in the fine chemical, pharmaceutical, and advanced material industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for catalytic systems.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions where required.

Basic Information

Product Name	5-Chloro-2,3-Difluoroisonicotinaldehyde
CAS No.	1333319-52-0
Molecular Formula	C6H2ClF2NO
Molecular Weight	177.54 g/mol
Synonyms	5-Chloro-2,3-difluoropyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 5-chloro-2,3-difluoro-; 5-Chloro-2,3-difluoro-4-formylpyridine; 5-Chloro-2,3-difluoropyridine-4-carboxaldehyde; 2,3-Difluoro-5-chloroisonicotinaldehyde; 5-Chloro-2,3-difluoro-4-pyridinecarboxaldehyde; 1333319-52-0; 5-Chloro-2,3-difluoropyridin-4-yl)methanone (tautomeric form)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-Difluoroisonicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects with material suitable for research use, pilot plant, and cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.