Description

Fmoc-Cyclopropylglycine CAS NO 1332765-55-5 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is critical for introducing the unique conformational constraints of the cyclopropyl ring into peptide backbones, enabling the development of novel bioactive molecules with enhanced metabolic stability and receptor selectivity. It is primarily utilized by pharmaceutical researchers, peptide manufacturers, and biotechnology companies engaged in drug discovery and development of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of complex peptides, particularly in research-scale and automated synthesizers.
• Peptidomimetic Drug Discovery: Used to incorporate the rigid, three-membered cyclopropyl ring into peptide sequences to modulate conformation, improve proteolytic stability, and explore novel structure-activity relationships (SAR).
• Chemical Biology Probes: Serves as a specialized monomer for synthesizing labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• API Intermediate Manufacturing: Acts as a critical raw material in the production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics targeting metabolic diseases, oncology, and infectious diseases.
• Academic & Institutional Research: Employed in university and government laboratories for fundamental research in organic chemistry, medicinal chemistry, and peptide science.
• Custom Peptide Service Providers: A vital reagent for CROs and CDMOs offering bespoke peptide synthesis services to the global biopharma industry.

Basic Information

Product Name	Fmoc-Cyclopropylglycine
CAS No.	1332765-55-5
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Cpg-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-aminocyclopropane-1-carboxylic acid; 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopropane-1-carboxylic acid; Fmoc-1-Aminocyclopropane-1-carboxylic acid; Fmoc-Cyclopropylgly-OH; (1-(((9H-Fluoren-9-yl)methoxy)carbonylamino)cyclopropane-1-carboxylic acid); N-Fmoc-1-aminocyclopropanecarboxylic acid; Fmoc-Acpc-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Cyclopropylglycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.