Description

tert-Butyl 2-(Chloromethyl)-4-Oxo-6,7,8,10-Tetrahydropyrimido[1,2-A][1,4]Diazepine-9(4H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Oncology Drug Development: A key scaffold for constructing molecules targeting specific kinases or other cancer-related pathways.
• CNS-Active Compound Synthesis: Employed in the research and development of potential treatments for neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry studies and novel methodology development.

Basic Information

Product Name	tert-Butyl 2-(Chloromethyl)-4-Oxo-6,7,8,10-Tetrahydropyrimido[1,2-A][1,4]Diazepine-9(4H)-Carboxylate
CAS No.	1330765-91-7
Molecular Formula	C16H20ClN3O3
Molecular Weight	337.80 g/mol
Synonyms	9-Boc-2-(chloromethyl)-4-oxo-6,7,8,10-tetrahydropyrimido[1,2-a][1,4]diazepine; tert-Butyl 2-(chloromethyl)-4-oxo-6,7,8,10-tetrahydropyrimido[1,2-a][1,4]diazepine-9(4H)-carboxylate; 2-(Chloromethyl)-9-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxo-6,7,8,10-tetrahydropyrimido[1,2-a][1,4]diazepine; 9-(tert-Butoxycarbonyl)-2-(chloromethyl)-4-oxo-6,7,8,10-tetrahydropyrimido[1,2-a][1,4]diazepine; Pyrimido[1,2-a][1,4]diazepine-9-carboxylic acid, 2-(chloromethyl)-4-oxo-6,7,8,10-tetrahydro-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Chloromethyl)-4-Oxo-6,7,8,10-Tetrahydropyrimido[1,2-A][1,4]Diazepine-9(4H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.