Description

(tert-Butoxy)Carbonyl D-His(Dnp)-Oh·Ipa is a specialized, protected amino acid derivative used in advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, structurally complex building blocks for pharmaceutical development. It is primarily utilized in the synthesis of peptide-based drugs, diagnostic agents, and biochemical research tools where precise stereochemistry and side-chain protection are essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key, protected D-histidine derivative for the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediates: In the research and development of novel therapeutic peptides targeting various disease pathways.
• Bioconjugation: For creating labeled peptides or peptide-protein conjugates used in diagnostic assays and targeted drug delivery systems.
• Biochemical Research: As a standard or reagent in studies involving histidine's role in enzyme catalysis and metal binding.
• Combinatorial Chemistry: For generating diverse peptide libraries in drug discovery platforms.
• API Development: Serving as a critical intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs) with specific chiral requirements.

Basic Information

Product Name	(tert-Butoxy)Carbonyl D-His(Dnp)-Oh·Ipa
CAS No.	1330286-54-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Boc-D-His(Dnp)-OH·Ipa; N-α-(tert-Butoxycarbonyl)-N-π-(2,4-dinitrophenyl)-D-histidine Isopropylammonium Salt; Boc-D-His(Dnp)-OH Isopropylamine Salt; (2S)-3-(2,4-Dinitrophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3H-imidazole-4-carboxylic acid - propan-2-amine (1:1); D-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-N-(2,4-dinitrophenyl)-, compd. with 2-propanamine (1:1); Protected D-Histidine derivative
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl D-His(Dnp)-Oh·Ipa is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with relevant pharmacopeial standards and customer-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.