Description

2-Ethynyl-5-Fluoro-4-Methoxypyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidine core functionalized with ethynyl, fluoro, and methoxy groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted small-molecule therapeutics. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of antiviral and oncology drugs, where its specific structure is leveraged for structure-activity relationship (SAR) studies and lead optimization.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel nucleoside analogs and kinase inhibitors.
• Antiviral Drug Research: Used in the development of active pharmaceutical ingredients (APIs) targeting viral polymerases and proteases.
• Oncology Therapeutics: Serves as a core scaffold for creating potential anti-cancer agents, particularly in targeted therapy programs.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent due to the reactive ethynyl group for click chemistry applications.
• Agrochemical Research: Investigated as a precursor for novel fungicides and herbicides leveraging its heterocyclic structure.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	2-Ethynyl-5-Fluoro-4-Methoxypyrimidine
CAS No.	1330044-12-6
Molecular Formula	C7H5FN2O
Molecular Weight	152.13 g/mol
Synonyms	5-Fluoro-4-methoxy-2-ethynylpyrimidine; 4-Methoxy-5-fluoro-2-ethynylpyrimidine; 2-Ethynyl-4-methoxy-5-fluoropyrimidine; 5-Fluoro-2-ethynyl-4-methoxypyrimidine; 1330044-12-6; 2-Ethynyl-5-fluoro-4-methoxypyrimidine; 4-Methoxy-5-fluoro-2-ethynyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-5-Fluoro-4-Methoxypyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity, prolonged exposure to air and moisture should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.