Description

5-Chloro-2-Ethynyl-4-Methoxypyrimidine is a high-purity, functionalized pyrimidine building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring both a chloro and an ethynyl substituent, makes it a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as the synthesis of kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted therapeutics, especially kinase inhibitors and other small-molecule drugs.
• Agrochemical Research: Used in the development of novel active ingredients for crop protection products.
• Chemical Biology: Serves as a probe or linker in the development of chemical tools and bioconjugates due to its reactive ethynyl group.
• Material Science: Potential monomer or precursor for the synthesis of specialized polymers and advanced organic materials.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it a suitable substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Click Chemistry: The alkyne functionality allows for efficient Huisgen 1,3-dipolar cycloaddition (click chemistry) with azides.

Basic Information

Product Name	5-Chloro-2-Ethynyl-4-Methoxypyrimidine
CAS No.	1330044-02-4
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	2-Ethynyl-5-chloro-4-methoxypyrimidine; 4-Methoxy-5-chloro-2-ethynylpyrimidine; 5-Chloro-4-methoxy-2-ethynylpyrimidine; 2-Ethynyl-4-methoxy-5-chloropyrimidine; 5-Chloro-2-ethynyl-4-methoxypyrimidine; Pyrimidine, 5-chloro-2-ethynyl-4-methoxy-; CAS 1330044-02-4
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Ethynyl-4-Methoxypyrimidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.