Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-Ethoxy-6-Fluoro-1,4-Dihydro-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Hydrochloride (1:1), Rel- is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents, particularly within the antibacterial quinolone class. It is essential for R&D chemists and process development scientists in pharmaceutical and biotechnology companies seeking to develop new drugs with targeted mechanisms of action.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation fluoroquinolone antibiotics and other bioactive molecules.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing new antibacterial therapies.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes and manufacturing processes.
• Biochemical Research: Employed in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes to understand resistance mechanisms.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and impurity profiling.
• Custom Synthesis & Contract Manufacturing: A vital compound for CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical industry.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-Ethoxy-6-Fluoro-1,4-Dihydro-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Hydrochloride (1:1), Rel-
CAS No.	1329642-65-0
Molecular Formula	C22H27FN4O4 • HCl
Molecular Weight	474.94 g/mol (Free base: 438.48 g/mol)
Synonyms	Rel-1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-((4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid hydrochloride; (R)-1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-((4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride; 1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-[(4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride (1:1); Antibacterial Quinolone Intermediate; Complex Fluoroquinolone Derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles where applicable for non-clinical material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.