Description

4-Chloro-2-Fluoro-3-Methoxybenzyl Bromide, 97% is a high-purity, multi-functional halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its precise molecular architecture, featuring chloro, fluoro, and methoxy substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and methoxy groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Serves as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Ligand and Catalyst Development: Utilized for synthesizing novel phosphine or nitrogen-based ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Libraries: A valuable starting material for generating fluorinated compound libraries in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Methoxybenzyl Bromide, 97%
CAS No.	1323966-35-3
Molecular Formula	C8H7BrClFO
Molecular Weight	253.50 g/mol
Synonyms	1-(Bromomethyl)-4-chloro-2-fluoro-3-methoxybenzene; (4-Chloro-2-fluoro-3-methoxyphenyl)methyl bromide; 3-Methoxy-4-chloro-2-fluorobenzyl bromide; 4-Chloro-2-fluoro-3-methoxybenzyl bromide; 2-Fluoro-3-methoxy-4-chlorobenzyl bromide; Benzene, 1-(bromomethyl)-4-chloro-2-fluoro-3-methoxy-; 4-Chloro-2-fluoro-3-methoxy-α-bromotoluene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Methoxybenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the specified 97% minimum assay. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, containers should be kept in opaque or amber glass and stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.