Description

R,R-Endo-Lurasidone Hcl is a high-purity, stereochemically defined intermediate of significant importance in modern pharmaceutical synthesis. This compound is critical for ensuring the precise stereochemistry required in the production of the active pharmaceutical ingredient Lurasidone HCl, an atypical antipsychotic. It is primarily required by advanced pharmaceutical manufacturers and research institutions engaged in the development and scale-up of complex, chiral drug molecules.

Application

• Key Chiral Intermediate for the synthesis of Lurasidone Hydrochloride API.
• Pharmaceutical Research & Development for studying structure-activity relationships and metabolic pathways.
• Process Chemistry in the optimization and validation of scalable synthetic routes for antipsychotic medications.
• Reference Standard for analytical method development and quality control in API manufacturing.
• Contract Manufacturing for companies specializing in the production of high-value, complex intermediates.

Basic Information

Product Name	R,R-Endo-Lurasidone Hcl
CAS No.	1318074-25-7
Molecular Formula	C28H37ClN4O2S
Molecular Weight	529.13 g/mol
Synonyms	(3aR,4R,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-1H-4,7-methanoisoindole-1,3,5-trione hydrochloride; (3aR,4R,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}hexahydro-4,7-methano-1H-isoindole-1,3,5-trione hydrochloride; R,R-Endo Isomer of Lurasidone Intermediate; Stereoisomer of Lurasidone HCl Intermediate; SM-13496 Isomer
EINECS	Contact for details

Quality Control

Our R,R-Endo-Lurasidone Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, stereochemical purity, and chemical purity exceeding 98.0%. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.