Description

Bax Inhibitor Peptide, Negative Control is a synthetic peptide designed as a critical negative control for apoptosis research. This compound is essential for validating the specificity and efficacy of active Bax inhibitor peptides in experimental models. It is primarily used by researchers and pharmaceutical developers in the fields of oncology, neurobiology, and cell biology to ensure the accuracy of mechanistic studies targeting the Bcl-2 protein family and intrinsic apoptotic pathways.

Application

• Specificity Control in Apoptosis Assays: Serves as a crucial negative control to distinguish specific Bax-mediated effects from non-specific peptide interactions in fluorescence-based, flow cytometry, and caspase activity assays.
• Validation of Drug Discovery Tools: Used to benchmark and validate the activity of novel therapeutic peptides and small molecules designed to inhibit Bax activation in cancer research.
• Mechanistic Studies in Neurodegeneration: Employed in models of Parkinson's, Alzheimer's, and ALS to rule out off-target effects when studying the role of mitochondrial apoptosis.
• Cardioprotection Research: Applied as a control in studies investigating ischemia-reperfusion injury and myocardial cell death to confirm the pathway specificity of experimental treatments.
• Cell Line and Model System Characterization: Essential for establishing baseline apoptosis levels in new cell lines or genetically modified animal models used for high-throughput screening.
• Quality Assurance for Reagent Kits: Incorporated into commercial and in-house apoptosis detection kits to ensure kit performance and result reliability.

Basic Information

Product Name	Bax Inhibitor Peptide, Negative Control
CAS No.	1315378-74-5
Molecular Formula	C41H71N13O11
Molecular Weight	922.1 g/mol
Synonyms	Bax Inhibiting Peptide Negative Control; BIP Negative Control; V5 Peptide; Bax Channel Blocker Negative Control; Phenylalanine-Valine-Proline-Methionine (FVPM) Peptide; H-DVPAFVPM-NH2; Asp-Val-Pro-Ala-Phe-Val-Pro-Met-NH2; Caspase-Inducing Peptide Control
EINECS	Contact for details

Quality Control

Every batch of our Bax Inhibitor Peptide, Negative Control is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high purity and batch-to-batch consistency suitable for sensitive biological research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be prepared in appropriate buffers, aliquoted, and stored at ≤ -70°C to avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, and standard aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.