Description

(4R)-Fmoc-4-Phenoxy-L-Proline CAS NO 1313390-76-9 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating complex peptide structures with enhanced stability and bioactivity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected proline analog for the Fmoc/t-Bu strategy, enabling the incorporation of a phenoxy-modified proline residue into peptide chains.
• Peptidomimetic Drug Discovery: Used to synthesize constrained peptide analogs and peptidomimetics to improve metabolic stability, bioavailability, and target selectivity for therapeutic candidates.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides used in studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• API Intermediate Production: Acts as a chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) for peptide drugs.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	(4R)-Fmoc-4-Phenoxy-L-Proline
CAS No.	1313390-76-9
Molecular Formula	C26H23NO5
Molecular Weight	429.46 g/mol
Synonyms	Fmoc-(4R)-4-phenoxy-L-proline; (4R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-phenoxy-L-proline; (4R)-4-Phenoxy-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; Fmoc-4-(PhO)-L-Pro-OH; N-α-Fmoc-4-phenoxy-L-proline; 1-Fmoc-4-phenoxy-L-proline; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-phenoxypyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (4R)-Fmoc-4-Phenoxy-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.