Description

3-(Acetylamino)-n-Fmoc-D-Alanine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptides with specific stereochemistry and functional groups. It is primarily utilized in pharmaceutical research, process development, and the production of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of custom peptide sequences.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Drug Design: Incorporates D-alanine and acetylated side chains to enhance metabolic stability and bioavailability in drug candidates.
• Bioconjugation and Labeling: Serves as a specialized linker or handle for attaching probes, tags, or other molecules to peptides.
• Academic and Industrial R&D: Essential for biochemical studies, structure-activity relationship (SAR) investigations, and library synthesis.
• Production of Diagnostic Reagents: Used in the manufacture of specialized peptides for diagnostic assays and kits.

Basic Information

Product Name	3-(Acetylamino)-n-Fmoc-D-Alanine
CAS No.	1313054-72-6
Molecular Formula	C21H22N2O5
Molecular Weight	382.41 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(acetylamino)-D-alanine; Fmoc-D-Ala(Ac)-OH; Nα-Fmoc-Nβ-acetyl-D-diaminopropionic acid; Fmoc-3-(Acetylamino)-D-alanine; N-Fmoc-3-acetamido-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-acetamidopropanoic acid
EINECS	Contact for details

Quality Control

Our 3-(Acetylamino)-n-Fmoc-D-Alanine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry standards for peptide synthesis building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.