Description

2-Hydroxy-D-Tryptophan is a specialized, non-proteinogenic amino acid derivative of D-tryptophan, distinguished by a hydroxyl group at the 2-position of the indole ring. This structural modification makes it a valuable chiral building block and intermediate in advanced pharmaceutical research and fine chemical synthesis. It is particularly sought after by research institutions and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, process development, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and metabolic regulators.
• Biochemical Research: Used as a precursor or standard in studies of enzyme kinetics, metabolic pathways, and neurotransmitter synthesis involving tryptophan derivatives.
• Peptide Synthesis: Serves as a modified amino acid residue for introducing specific functional groups into synthetic peptides and peptidomimetics to alter their biological activity or stability.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Asymmetric Synthesis: Utilized as a chiral pool starting material or auxiliary in the synthesis of enantiomerically pure compounds for agrochemicals and advanced materials.

Basic Information

Product Name	2-Hydroxy-D-Tryptophan
CAS No.	1313054-66-8
Molecular Formula	C11H12N2O3
Molecular Weight	220.23 g/mol
Synonyms	(R)-2-Hydroxytryptophan; D-2-Hydroxytryptophan; (2R)-2-Amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid; 2-OH-D-Trp; 2-Hydroxy-D-Trp; (R)-2-Hydroxy-1H-indole-3-alanine; 2-Hydroxy-D-tryptophan, CAS 1313054-66-8
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.