Description

4-Carboxy-L-Tryptophan is a modified amino acid derivative of L-tryptophan, featuring an additional carboxylic acid functional group. This structural modification makes it a valuable non-natural amino acid and a key chiral building block for advanced research and synthesis. It is primarily utilized in pharmaceutical development, biochemical research, and as a precursor for peptide-based therapeutics. This compound is essential for scientists and manufacturers requiring high-purity, specialized amino acids for innovative applications.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a non-natural amino acid in metabolic pathway studies, enzyme substrate research, and protein engineering.
• Peptide Synthesis: An important raw material for solid-phase and solution-phase peptide synthesis, enabling the introduction of unique carboxylic acid functionality.
• Proteomics & Labeling: Potential use in the development of chemical probes, affinity tags, and mass spectrometry standards for proteomic analysis.
• Nutraceutical Development: Investigated for use in advanced nutritional supplements and functional food ingredients due to its tryptophan backbone.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and new molecular entity discovery.

Basic Information

Product Name	4-Carboxy-L-Tryptophan
CAS No.	1313054-53-3
Molecular Formula	C12H12N2O4
Molecular Weight	248.23 g/mol
Synonyms	L-4-Carboxytryptophan; (2S)-2-Amino-3-(4-carboxy-1H-indol-3-yl)propanoic acid; 4-Carboxy-L-Trp; 4-Carboxytryptophan; 4-CTrp; 1H-Indole-4-carboxylic acid, 3-(2-amino-1-carboxyethyl)-, (S)-; 4-Carboxy-DL-tryptophan (related); Tryptophan-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Carboxy-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity analysis, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO-guided standards ensures consistent quality suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.