Description

D-Glutamine, N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-9H-Xanthen-9-Yl- is a sophisticated, orthogonally protected derivative of the amino acid D-glutamine, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring high-purity, chiral building blocks for peptide synthesis and medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical suppliers engaged in the development of novel therapeutic peptides and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected D-glutamine residue for the controlled incorporation of this non-natural enantiomer into peptide chains, enabling the study of structure-activity relationships.
• Medicinal Chemistry & Drug Discovery: Used as a chiral intermediate in the research and development of peptide-based pharmaceuticals, protease inhibitors, and other bioactive compounds.
• Bioconjugation and Probe Development: The Fmoc and Xan protecting groups allow for selective deprotection, making it valuable for creating labeled peptides or protein conjugates for diagnostic and research purposes.
• Chemical Biology Research: Employed in the synthesis of custom peptides to investigate enzyme mechanisms, receptor-ligand interactions, and other biological processes.
• Fine Chemical Intermediate: Acts as a high-value starting material or intermediate for the synthesis of more complex, specialized molecules in contract research and manufacturing (CRMO) settings.

Basic Information

Product Name	D-Glutamine, N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-9H-Xanthen-9-Yl-
CAS No.	1313054-52-2
Molecular Formula	C33H28N2O6
Molecular Weight	548.59 g/mol
Synonyms	Fmoc-D-Gln(Xan)-OH; Nα-Fmoc-Nγ-xanthenyl-D-glutamine; Nα-(9-Fluorenylmethoxycarbonyl)-Nγ-(9H-xanthen-9-yl)-D-glutamine; Fmoc-D-glutamine(Xan)-OH; (2R)-5-[(9H-Xanthen-9-yl)amino]-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]-5-oxopentanoic acid; D-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-, N-9H-xanthen-9-yl-; Fmoc-D-Gln(Xan)
EINECS	Contact for details

Quality Control

Our D-Glutamine, N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-9H-Xanthen-9-Yl- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical purity, and identity confirmation. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.