Description

n-Fmoc-6-Methoxy-Dl-Tryptophan CAS NO 1313032-63-1 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for researchers developing novel peptides with enhanced stability and biological activity. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on peptide-based drug discovery and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides, particularly those incorporating modified tryptophan residues.
• Pharmaceutical Research & Development: Used in the discovery and development of therapeutic peptides, including hormone analogs, enzyme inhibitors, and antimicrobial agents.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescently labeled or biotinylated peptides for diagnostic assays and cellular imaging studies.
• Structure-Activity Relationship (SAR) Studies: Enables the systematic modification of peptide sequences to investigate the role of methoxy-tryptophan on binding affinity and metabolic stability.
• Combinatorial Chemistry Libraries: Incorporated into diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: Utilized in biochemistry and chemical biology laboratories for studying protein-protein interactions and peptide folding.

Basic Information

Product Name	n-Fmoc-6-Methoxy-Dl-Tryptophan
CAS No.	1313032-63-1
Molecular Formula	C₂₈H₂₆N₂O₅
Molecular Weight	470.52 g/mol
Synonyms	Fmoc-6-MeO-DL-Trp-OH; Fmoc-6-Methoxy-DL-tryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-methoxy-DL-tryptophan; 6-Methoxy-DL-tryptophan, N-Fmoc derivative; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(6-methoxy-1H-indol-3-yl)propanoic acid; Fmoc-6-methoxy-Trp-OH; Fmoc-6-methoxy-DL-Trp; N-α-Fmoc-6-methoxy-DL-tryptophan
EINECS	Contact for details

Quality Control

Our n-Fmoc-6-Methoxy-Dl-Tryptophan is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed by HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.