Description

2-Bromo-1-(2-Chloropyrimidin-4-Yl)Ethanone is a high-purity halogenated pyrimidine building block of significant importance in modern synthetic chemistry. Its bifunctional reactive sites make it a versatile intermediate for constructing complex heterocyclic scaffolds. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential intermediate in the creation of specialty polymers and organic electronic materials due to its functionalized aromatic system.
• Cross-Coupling Reactions: The bromo and chloro substituents make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Nucleophilic Substitution: The reactive halogens allow for sequential functionalization, enabling the introduction of diverse amine, alkoxy, or thioether groups.

Basic Information

Product Name	2-Bromo-1-(2-Chloropyrimidin-4-Yl)Ethanone
CAS No.	1312815-21-6
Molecular Formula	C6H4BrClN2O
Molecular Weight	235.47 g/mol
Synonyms	2-Bromo-1-(2-chloropyrimidin-4-yl)ethan-1-one; 4-Acetyl-2-chloropyrimidine, 2-bromo derivative; 2-Chloro-4-(2-bromoacetyl)pyrimidine; 1-(2-Chloro-4-pyrimidinyl)-2-bromoethanone; 2-Bromo-1-(2-chloro-4-pyrimidinyl)ethanone; α-Bromo-2-chloro-4-pyrimidyl methyl ketone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(2-Chloropyrimidin-4-Yl)Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.