Description

3-Cyano-1-Azetidinesulfonylchloride is a high-value, multi-functional chemical intermediate featuring a reactive sulfonyl chloride group and a cyano-substituted azetidine ring. This compound matters for its critical role in facilitating the synthesis of novel sulfonamide derivatives, which are pivotal scaffolds in modern medicinal chemistry and agrochemical development. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for constructing targeted molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting enzymes via sulfonamide inhibition.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with sulfonamide functionalities.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with specialized properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.

Basic Information

Product Name	3-Cyano-1-Azetidinesulfonylchloride
CAS No.	1310734-08-7
Molecular Formula	C4H5ClN2O2S
Molecular Weight	180.61 g/mol
Synonyms	1-Azetidinesulfonyl chloride, 3-cyano-; 3-Cyanoazetidine-1-sulfonyl chloride; Azetidine-1-sulfonyl chloride, 3-cyano-; 3-Cyano-1-(chlorosulfonyl)azetidine; 1-(Chlorosulfonyl)-3-cyanoazetidine; 3-Cyanoazetidine sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Cyano-1-Azetidinesulfonylchloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.