Description

tert-Butyl 3-(Chlorosulphonyl)Azetidine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-3-(Chlorosulphonyl)Azetidine is a high-value, multifunctional azetidine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in the reactive chlorosulfonyl group, which enables efficient introduction of the azetidine sulfonamide scaffold, a privileged structure in modern medicinal chemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients targeting a range of diseases and crop protection solutions.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing small molecule drug candidates, especially those incorporating azetidine sulfonamide moieties for improved metabolic stability and target binding.
• API Development: Used in the research and scale-up of Active Pharmaceutical Ingredients (APIs) for therapeutic areas such as oncology, central nervous system (CNS) disorders, and infectious diseases.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probes: Utilized to create tool compounds and probes for studying enzyme function and biological pathways in R&D settings.
• Peptidomimetics: Incorporation into peptide analogs to enhance pharmacological properties and oral bioavailability.
• Material Science Research: Potential monomer or cross-linker in the development of specialized polymers with unique properties.

Basic Information

Product Name	tert-Butyl 3-(Chlorosulphonyl)Azetidine-1-Carboxylate, 1-(tert-Butoxycarbonyl)-3-(Chlorosulphonyl)Azetidine
CAS No.	1310732-18-3
Molecular Formula	C9H16ClNO4S
Molecular Weight	269.75 g/mol
Synonyms	1-Boc-3-(chlorosulfonyl)azetidine; 3-(Chlorosulfonyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine; tert-Butyl 3-(chlorosulfonyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)azetidine-3-sulfonyl chloride; Azetidine-1-carboxylic acid, 3-(chlorosulfonyl)-, 1,1-dimethylethyl ester; Boc-Azetidine-3-sulfonyl Chloride; 3-(Chlorosulfonyl)azetidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Chlorosulphonyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.