Description

(S)-(9H-Fluoren-9-Yl)Methoxy]Carbonyl 2-Amino-3-Ethyl-Pentanoic Acid is a specialized, non-natural amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group, a cornerstone reagent in modern solid-phase peptide synthesis (SPPS). Its value lies in enabling the controlled, sequential assembly of complex peptides and peptidomimetics, particularly those requiring branched-chain or sterically hindered amino acid residues. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science, where precise molecular construction is critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of therapeutic peptides and peptide hormones.
• Pharmaceutical Research: Used in the discovery and development of novel drug candidates, especially peptidomimetics and enzyme inhibitors.
• Bioconjugation: Serves as a specialized linker or spacer molecule for attaching peptides to other biomolecules, polymers, or surfaces.
• Combinatorial Chemistry: A valuable building block for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Academic Research: Employed in biochemistry and organic chemistry laboratories for studying protein structure-function relationships and synthesizing custom peptides.
• Production of Custom Peptides: Used by CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific peptide manufacturing.

Basic Information

Product Name	(S)-(9H-Fluoren-9-Yl)Methoxy]Carbonyl 2-Amino-3-Ethyl-Pentanoic Acid
CAS No.	1310680-47-7
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-2-Amino-3-ethylpentanoic acid; Fmoc-Aep-OH; Fmoc-L-2-Amino-3-ethylpentanoic acid; (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-ethylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-ethyl-L-norvaline; Fmoc-3-Ethyl-norvaline; Nα-Fmoc-2-amino-3-ethylpentanoic acid; Boc-Aep-OH (related, but different protecting group)
EINECS	Contact for details

Quality Control

Our (S)-(9H-Fluoren-9-Yl)Methoxy]Carbonyl 2-Amino-3-Ethyl-Pentanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.