Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-β-Methylisoleucine CAS NO 1310680-40-0 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block, offering precise stereochemical control to enhance the metabolic stability and biological activity of novel therapeutic peptides. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the creation of peptide-based drugs, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of complex peptide chains, particularly where the D-β-methylisoleucine moiety is required.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development of novel peptide therapeutics targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Used to introduce conformational constraints and enhance proteolytic stability in the design of peptidomimetic compounds.
• Bioconjugation: Acts as a specialized linker or modified residue in the conjugation of peptides to other molecules, such as dyes, polymers, or drug carriers.
• Chemical Biology Research: Employed in the study of enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of bioactive peptides.
• Process Development: Used in scaling up GMP-compliant manufacturing processes for clinical and commercial peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-β-Methylisoleucine
CAS No.	1310680-40-0
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-D-β-MeIle-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-β-methylisoleucine; Fmoc-D-β-methylisoleucine; (2S,3S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methylpentanoic acid; Fmoc-D-β-methyl-Ile-OH; N-Fmoc-D-β-methylisoleucine; Fmoc-(2S,3S)-3-methyl-2-aminopentanoic acid; Fmoc-D-β-MeIle
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl D-β-Methylisoleucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.