Description

4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Dimethylbutanoic Acid is a specialized Fmoc-protected amino acid derivative, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, where the Fmoc group provides orthogonal protection for the amino functionality. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly in solid-phase peptide synthesis (SPPS) for creating therapeutic peptides, diagnostic agents, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of peptides using Fmoc chemistry protocols.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, hormones, and enzyme inhibitors.
• Peptidomimetic Design: Incorporates the unique 2,2-dimethylbutanoic acid backbone to create analogs with enhanced metabolic stability and bioavailability.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new lead compounds.
• Academic Research: A valuable reagent for studying peptide structure-activity relationships and synthetic methodology.

Basic Information

Product Name	4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Dimethylbutanoic Acid
CAS No.	1310680-24-0
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-2,2-dimethyl-β-alanine; Fmoc-Dmb-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,2-dimethyl-β-alanine; 4-[(Fmoc-amino)]-2,2-dimethylbutanoic acid; 2,2-Dimethyl-3-[(9H-fluoren-9-ylmethoxy)formamido]propanoic Acid; Fmoc-3-amino-2,2-dimethylpropanoic acid; N-Fmoc-2,2-dimethyl-β-alanine
EINECS	Contact for details

Quality Control

Our 4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Dimethylbutanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.