Description

1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-3,3-Dimethylpyrrolidine-2-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in the production of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled assembly of peptide chains, particularly those requiring sterically hindered or modified amino acids.
• Peptidomimetic Drug Discovery: Used to synthesize non-natural peptide analogs with enhanced metabolic stability, bioavailability, and target specificity for therapeutic applications.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse compound libraries for high-throughput screening against biological targets.
• Bioconjugation and Probe Development: Facilitates the site-specific incorporation of functional handles or labels into peptides for diagnostic and research tools.
• Academic and Industrial Research: Employed in methodological studies and the synthesis of reference standards for analytical and pharmacological evaluation.

Basic Information

Product Name	1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-3,3-Dimethylpyrrolidine-2-Carboxylic Acid
CAS No.	1310680-20-6
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-3,3-Dimethylproline; Fmoc-Dmp-OH; 1-Fmoc-3,3-dimethylproline; 1-[(9-Fluorenylmethoxycarbonyl)-3,3-dimethylproline; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-dimethylpyrrolidine-2-carboxylic acid; Fmoc-3,3-dimethyl-L-proline; Fmoc-Dimethylproline-OH
EINECS	Contact for details

Quality Control

Our production of 1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-3,3-Dimethylpyrrolidine-2-Carboxylic Acid adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.