Description

3,5-Difluoro-4-Formyl-n-Methylbenzamide is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly due to the strategic placement of its formyl and amide functional groups adjacent to fluorine atoms, which can dramatically influence electronic properties and binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and receptor modulator research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoro motif can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials for their unique optoelectronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes used in diagnostic and imaging applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	3,5-Difluoro-4-Formyl-n-Methylbenzamide
CAS No.	1308849-85-5
Molecular Formula	C9H7F2NO2
Molecular Weight	199.16 g/mol
Synonyms	4-Formyl-3,5-difluoro-N-methylbenzamide; 3,5-Difluoro-4-formyl-N-methylbenzamide; N-Methyl-3,5-difluoro-4-formylbenzamide; Benzamide, 3,5-difluoro-4-formyl-N-methyl-; 1308849-85-5; 4-Carbamoyl-2,6-difluorobenzaldehyde (tautomeric form)
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Formyl-n-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.