Description

1-(2-Fluoro-6-(Trifluoromethyl)Benzyl)-6-Methyl-5-(Piperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione is a sophisticated pyrimidine-based heterocyclic compound designed for advanced research and development. This molecule is of significant interest due to its complex structure, which incorporates fluorine and trifluoromethyl groups known to enhance metabolic stability and binding affinity in bioactive molecules. It serves as a critical pharmaceutical intermediate or reference standard for medicinal chemistry programs targeting novel therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Tool Compound: Employed in vitro to study enzyme inhibition or receptor modulation for target validation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Preclinical Development: Supports early-stage drug discovery, including pharmacokinetic and pharmacodynamic profiling.
• Custom Synthesis Starting Material: Provides a versatile precursor for the preparation of more complex, targeted molecular libraries.

Basic Information

Product Name	1-(2-Fluoro-6-(Trifluoromethyl)Benzyl)-6-Methyl-5-(Piperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	1308380-33-7
Molecular Formula	C18H18F4N4O2
Molecular Weight	398.36 g/mol
Synonyms	5-(Piperazin-1-yl)-6-methyl-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}pyrimidine-2,4(1H,3H)-dione; 1-[(2-Fluoro-6-(trifluoromethyl)phenyl)methyl]-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione; 1308380-33-7; UNII-7J8W8Q5V6P; 7J8W8Q5V6P; 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4-dione; 5-Piperazinyl-6-methyl-1-(2-fluoro-6-trifluoromethylbenzyl)uracil
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-6-(Trifluoromethyl)Benzyl)-6-Methyl-5-(Piperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.