Description

5-[4-(Chloroacetyl)Piperazin-1-Yl]Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine-pyrimidine core functionalized with a chloroacetyl group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step manufacturing processes of final active pharmaceutical ingredients requiring a functionalized piperazine moiety.
• Bioconjugation & Probe Development: The reactive chloroacetyl group enables its use in creating chemical probes or conjugates for biochemical and diagnostic applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Item	Details
Product Name	5-[4-(Chloroacetyl)Piperazin-1-Yl]Pyrimidine
CAS No.	1306739-48-9
Molecular Formula	C10H12ClN5O
Molecular Weight	253.69 g/mol
Synonyms	5-(4-(Chloroacetyl)piperazin-1-yl)pyrimidine; 1-(4-Pyrimidin-5-ylpiperazin-1-yl)-2-chloroethanone; 2-Chloro-1-[4-(5-pyrimidinyl)-1-piperazinyl]ethanone; 5-(4-(2-Chloroacetyl)piperazin-1-yl)pyrimidine; Chloroacetyl-piperazinyl-pyrimidine; CAS 1306739-48-9
EINECS	Contact for details

Quality Control

Our 5-[4-(Chloroacetyl)Piperazin-1-Yl]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.