Description

Dde-D--Lys(Fmoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its critical role in enabling complex, multi-step solid-phase peptide synthesis (SPPS) by providing selective deprotection strategies. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and chemical biology who require high-purity building blocks for creating novel peptide-based therapeutics and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of complex peptides.
• Orthogonal Protection Strategies: Enables selective deprotection of specific amino acid side chains using hydrazine, allowing for the synthesis of branched or cyclic peptide structures.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of labels, tags, or other molecules to peptides for diagnostic or research applications.
• Combinatorial Chemistry: Serves as a valuable reagent in libraries for drug discovery and lead optimization.
• Academic and Industrial Research: A fundamental tool for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Dde-D--Lys(Fmoc)-Oh
CAS No.	1301706-71-7
Molecular Formula	C33H35N3O6
Molecular Weight	569.65 g/mol
Synonyms	Nα-Fmoc-Nε-(1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-D-lysine; Fmoc-D-Lys(Dde)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-D-lysine; Fmoc-D-Lys(Nε-Dde)-OH; Dde-D-Lys(Fmoc)-OH; (2R)-6-[[2-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Dde-D--Lys(Fmoc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.