Description

Boc-D-Hocys(Trt)-Oh is a protected derivative of the non-proteinogenic amino acid D-homocysteine, featuring tert-butyloxycarbonyl (Boc) and trityl (Trt) protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of D-homocysteine while preventing unwanted side reactions. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptides with specific chiral centers, structural modifications, or for studying metabolic pathways related to homocysteine.

Application

• Pharmaceutical Intermediates: Key chiral building block for the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in Fmoc/t-Bu and Boc/Bzl solid-phase peptide synthesis strategies for the site-specific introduction of D-homocysteine residues.
• Biochemical Research: A vital tool for studying homocysteine metabolism, enzyme-substrate interactions, and the biological effects of D-amino acid containing peptides.
• Proteomics & Labeling: Can be utilized for the chemical modification of peptides and proteins, facilitating tracking, conjugation, or functionalization studies.
• Material Science: Potential use in creating specialized peptide polymers or biomaterials with unique structural or responsive properties.

Basic Information

Product Name	Boc-D-Hocys(Trt)-Oh
CAS No.	1301706-43-3
Molecular Formula	C30H35NO4S
Molecular Weight	505.67 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-D-homocysteine(trityl)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-4-(tritylthio)butanoic acid; Boc-D-homocysteine(Trt)-OH; Boc-D-Hcy(Trt)-OH; Boc-D-Hocys(Trityl)-OH; N-Boc-D-homocysteine trityl ester; D-Homocysteine, N-[(1,1-dimethylethoxy)carbonyl]-, S-(triphenylmethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-D-Hocys(Trt)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.