Description

n-α-T-Butyloxycarbonyl-n-ε-(2-Nitrobenzenesulfonyl)-L-Lysine, also known as n-α-Boc-n-ε-Nosyl-L-Lysine is a sophisticated, orthogonally protected derivative of the essential amino acid L-Lysine, designed for advanced peptide synthesis and medicinal chemistry. This compound is critical for researchers and manufacturers requiring precise, sequential deprotection strategies to build complex biomolecules. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers engaged in the development of peptide-based therapeutics, diagnostics, and novel chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block where the Boc group protects the α-amino group and the Nosyl (2-nitrobenzenesulfonyl) group protects the ε-amino group, allowing for selective deprotection.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel peptide drugs, enzyme inhibitors, and targeted therapeutics that require specific lysine side-chain modifications.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse libraries of compounds for high-throughput screening against biological targets.
• Bioconjugation and Probe Development: The Nosyl protecting group can be utilized in further functionalization strategies, making this compound useful for creating fluorescent probes, affinity labels, or antibody-drug conjugates (ADCs).
• Academic Research: Employed in university and institutional labs for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.
• Process Development & Scale-Up: Supports the transition from milligram-scale discovery to gram or kilogram-scale production for clinical trial material (CTM) and commercial manufacturing.

Basic Information

Product Name	n-α-T-Butyloxycarbonyl-n-ε-(2-Nitrobenzenesulfonyl)-L-Lysine
CAS No.	1301706-36-4
Molecular Formula	C17H25N3O8S
Molecular Weight	431.46 g/mol
Synonyms	n-α-Boc-n-ε-Nosyl-L-Lysine; Boc-Lys(Nosyl)-OH; Boc-Lys(2-Nosyl)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-6-((2-nitrobenzenesulfonyl)amino)hexanoic acid; Nα-Boc-Nε-Nosyl-L-lysine; Nα-Boc-Nε-(2-nitrobenzenesulfonyl)-L-lysine; L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(2-nitrophenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our n-α-Boc-n-ε-Nosyl-L-Lysine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates. Specifications are designed to meet the rigorous demands of advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.