Description

Apraglutide is a synthetic, long-acting glucagon-like peptide-2 (GLP-2) analog designed for enhanced stability and biological activity. This compound is of significant interest for its therapeutic potential in treating gastrointestinal disorders and conditions involving intestinal failure. It is primarily utilized by pharmaceutical research organizations and biotechnology companies engaged in metabolic and gastrointestinal drug development. Apraglutide CAS NO 1295353-98-8 represents a high-purity, research-grade material critical for preclinical and clinical-stage investigations.

Application

• Pharmaceutical R&D: Key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics for short bowel syndrome (SBS).
• Preclinical Studies: Used in animal models to evaluate efficacy in promoting intestinal adaptation, nutrient absorption, and reducing dependence on parenteral nutrition.
• Formulation Development: Serves as a reference standard in the development of stable injectable formulations, including lyophilized powders and solutions.
• Biochemical Research: Tool compound for studying GLP-2 receptor signaling pathways, mechanism of action, and structure-activity relationships (SAR).
• Clinical Trial Material (CTM): Supplied under GMP-like conditions for use in Phase I-III clinical trials investigating intestinal failure therapies.
• Analytical Standard: High-purity reference material for quality control (QC) and analytical method development (e.g., HPLC, LC-MS).

Basic Information

Item	Details
Product Name	Apraglutide
CAS No.	1295353-98-8
Molecular Formula	C172H267N45O55
Molecular Weight	3768.2 g/mol
Synonyms	FE 203799; GLP-2 Analog; Teduglutide analog; FE-203799; Long-acting GLP-2; Apraglutide acetate; GLP-2 (human) analog; [Gly2]GLP-2; Glucagon-like peptide-2 analog
EINECS	Contact for details

Quality Control

Our Apraglutide is manufactured and controlled to meet the stringent requirements for pharmaceutical research materials. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, mass spectrometry (MS) for identity confirmation, and tests for related substances and residual solvents. A comprehensive Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	95.0% - 105.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	1.0% - 10.0%
Peptide Content (Amino Acid Analysis)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.