Description

4-(4,4-Difluoropiperidin-1-Yl)-3,5-Difluoroaniline is a high-value, multi-fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its core value lies in its unique piperidine-aniline hybrid structure, which serves as a critical pharmacophore for modulating the biological activity and physicochemical properties of novel compounds. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients in drug discovery and crop protection programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorinated motifs enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers and advanced materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrogen donor atoms and rigid structure.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and for introducing fluorine atoms into complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	4-(4,4-Difluoropiperidin-1-Yl)-3,5-Difluoroaniline
CAS No.	1292836-32-8
Molecular Formula	C11H12F4N2
Molecular Weight	248.22 g/mol
Synonyms	3,5-Difluoro-4-(4,4-difluoropiperidin-1-yl)aniline; 1-(2,6-Difluoro-4-aminophenyl)-4,4-difluoropiperidine; 4-(4,4-Difluoro-1-piperidinyl)-3,5-difluorobenzenamine; 1292836-32-8; Benzenamine, 3,5-difluoro-4-(4,4-difluoropiperidin-1-yl)-; 4,4-Difluoro-1-(2,6-difluoro-4-aminophenyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-(4,4-Difluoropiperidin-1-Yl)-3,5-Difluoroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.