Description

tert-Butyl 4-Fluoro-2-Hydroxybenzylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fluorinated phenolic structure. This compound is critical for medicinal chemists as it serves as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system and inflammatory diseases. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring a fluorinated phenolic moiety for enhanced bioavailability and metabolic stability.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteolytic enzymes, leveraging the carbamate and hydroxyl functional groups.
• Kinase Inhibitor Scaffolds: Serves as a core structural element in the design and synthesis of small-molecule kinase inhibitors for oncology and immunology applications.
• Peptidomimetic Chemistry: Employed to introduce fluorinated benzyl groups into peptide analogs to modulate their physicochemical properties and receptor binding affinity.
• Agrochemical Synthesis: Acts as an intermediate in the research and development of new-generation herbicides and fungicides with improved efficacy.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with specific optical or surface properties.

Basic Information

Product Name	tert-Butyl 4-Fluoro-2-Hydroxybenzylcarbamate
CAS No.	1292211-10-9
Molecular Formula	C₁₂H₁₆FNO₃
Molecular Weight	241.26 g/mol
Synonyms	Boc-4-Fluoro-2-hydroxybenzylamine; N-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxybenzylamine; 4-Fluoro-2-hydroxybenzylcarbamic acid tert-butyl ester; 2-Hydroxy-4-fluorobenzylcarbamic acid tert-butyl ester; tert-Butyl N-[(4-fluoro-2-hydroxyphenyl)methyl]carbamate; (4-Fluoro-2-hydroxybenzyl)carbamic acid tert-butyl ester; Boc-4F-2-OH-Bn-NH₂
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoro-2-Hydroxybenzylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.