Description

N2-[4-(Trifluoromethyl)Phenyl]Pyrimidine-2,5-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine-diamine core and trifluoromethylphenyl substituent. This compound is essential for the synthesis of targeted small-molecule therapeutics, particularly in oncology and antiviral research, where its specific structure enables precise drug-receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers developing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Agrochemical Research: Used in developing advanced fungicides and herbicides, leveraging the bioactivity of the pyrimidine scaffold.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, where the trifluoromethyl group enhances thermal and chemical stability.
• Organic Synthesis: A versatile reagent for constructing complex heterocyclic compounds in academic and industrial research settings.
• Bioconjugation & Probe Development: Utilized in creating fluorescent probes and biochemical tools for diagnostic and research applications.

Basic Information

Product Name	N2-[4-(Trifluoromethyl)Phenyl]Pyrimidine-2,5-Diamine
CAS No.	1291798-89-4
Molecular Formula	C11H9F3N4
Molecular Weight	254.21 g/mol
Synonyms	2,5-Pyrimidinediamine, N2-[4-(trifluoromethyl)phenyl]-; 2-Amino-5-[[4-(trifluoromethyl)phenyl]amino]pyrimidine; 5-Amino-2-((4-(trifluoromethyl)phenyl)amino)pyrimidine; N-(4-(Trifluoromethyl)phenyl)pyrimidine-2,5-diamine; 1291798-89-4; 2,5-Diamino-N-(4-(trifluoromethyl)phenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our N2-[4-(Trifluoromethyl)Phenyl]Pyrimidine-2,5-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.