Description

Dimethyl 2-(5-Bromopyrimidin-2-Yl)Malonate is a high-purity brominated pyrimidine derivative, a crucial building block in modern synthetic organic chemistry. This compound matters because it serves as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel compounds with targeted biological activities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic electronics and advanced polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO laboratories.
• Custom Synthesis & Scale-up: A starting material for contract manufacturing organizations (CMOs) producing bespoke intermediates under cGMP or ISO standards.

Basic Information

Product Name	Dimethyl 2-(5-Bromopyrimidin-2-Yl)Malonate
CAS No.	1291487-28-9
Molecular Formula	C9H9BrN2O4
Molecular Weight	289.08 g/mol
Synonyms	Dimethyl (5-bromopyrimidin-2-yl)malonate; 2-(5-Bromopyrimidin-2-yl)malonic acid dimethyl ester; Malonic acid, (5-bromo-2-pyrimidinyl)-, dimethyl ester; 5-Bromo-2-pyrimidinylmalonic acid dimethyl ester; (5-Bromopyrimidin-2-yl)propanedioic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Dimethyl 2-(5-Bromopyrimidin-2-Yl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We support development and commercial projects requiring consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened in a moisture-controlled environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.