Description

(R)-tert-Butyl 3-(Pyrimidin-2-Ylamino)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected intermediate of significant value in modern synthetic chemistry. Its primary importance lies in its role as a key precursor for the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and antiviral drug candidates.
• Kinase Inhibitor Synthesis: Serves as a core structural component in the preparation of potent and selective kinase inhibitors, a major class of targeted therapies.
• Medicinal Chemistry & Lead Optimization: Used in structure-activity relationship (SAR) studies to explore and optimize the pharmacological profile of drug-like molecules.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for the commercial manufacturing of advanced intermediates.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or scaffold to introduce stereochemical complexity in multi-step synthetic sequences.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development services for the biopharma industry.

Basic Information

Product Name	(R)-tert-Butyl 3-(Pyrimidin-2-Ylamino)Pyrrolidine-1-Carboxylate
CAS No.	1289585-45-0
Molecular Formula	C13H21N5O2
Molecular Weight	279.34 g/mol
Synonyms	1-Boc-3-(2-pyrimidinylamino)-(R)-pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-(pyrimidin-2-ylamino)pyrrolidine; tert-Butyl (3R)-3-(pyrimidin-2-ylamino)pyrrolidine-1-carboxylate; (R)-N-(1-Boc-3-pyrrolidinyl)-2-pyrimidinamine; (R)-tert-Butyl 3-((pyrimidin-2-yl)amino)pyrrolidine-1-carboxylate; (R)-1-Boc-3-(2-aminopyrimidinyl)pyrrolidine; (R)-3-(Pyrimidin-2-ylamino)-1-Boc-pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(Pyrimidin-2-Ylamino)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.