Description

(R)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a key synthon for constructing complex, biologically active molecules, particularly in the development of targeted therapeutics. This compound is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Drug Discovery & Medicinal Chemistry: Used in research and development for constructing novel chemical libraries and lead optimization candidates.
• Process Chemistry & Scale-Up: Serves as a defined intermediate in the commercial-scale manufacturing of complex drug molecules.
• Bioconjugation & Probe Development: The reactive amine and ester functionalities make it suitable for creating labeled compounds or conjugates for biological studies.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis routes.

Basic Information

Item	Details
Product Name	(R)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1289585-36-9
Molecular Formula	C14H20ClN5O2
Molecular Weight	325.79 g/mol
Synonyms	(R)-tert-Butyl 3-((6-chloropyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (R)-3-((6-Chloro-4-pyrimidinyl)amino)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; (R)-3-((6-Chloropyrimidin-4-yl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; (R)-N-(6-Chloropyrimidin-4-yl)pyrrolidin-3-amine-1-carboxylic acid tert-butyl ester; (R)-Boc-3-amino-4-(6-chloropyrimidinyl)pyrrolidine; (R)-3-(6-Chloro-4-pyrimidinylamino)pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee supply chain transparency and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.