Description

3-(5-Fluoro-Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a versatile pyrrolidine-pyrimidine scaffold for constructing novel drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry R&D: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and commercial route development for APIs.
• Oncology Drug Development: Employed in the research of targeted cancer therapies due to its fluoropyrimidine moiety.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic and bioorganic chemistry.

Basic Information

Product Name	3-(5-Fluoro-Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1289385-93-8
Molecular Formula	C13H18FN5O2
Molecular Weight	295.31 g/mol
Synonyms	tert-Butyl 3-[(5-fluoropyrimidin-2-yl)amino]pyrrolidine-1-carboxylate; 1-Boc-3-[(5-fluoropyrimidin-2-yl)amino]pyrrolidine; 3-[(5-Fluoropyrimidin-2-yl)amino]-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 3-[(5-fluoropyrimidin-2-yl)amino]-1-pyrrolidinecarboxylate; 3-(5-Fluoro-2-pyrimidinylamino)-1-pyrrolidinecarboxylic Acid tert-Butyl Ester; 3-(5-F-Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid t-Butyl Ester; Boc-3-(5-fluoro-pyrimidin-2-ylamino)-pyrrolidine
EINECS	Contact for details

Quality Control

Our production of 3-(5-Fluoro-Pyrimidin-2-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. The material is manufactured and tested under current Good Manufacturing Practice (cGMP) principles suitable for pharmaceutical development. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.