Description

2-(4-Chloro-5-Methyl-Pyrimidin-2-Yloxymethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting oncology and central nervous system (CNS) disorders.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety in the research and development of new chemical entities (NCEs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery laboratories.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial APIs.
• Chemical Synthesis: Employed in academic and industrial research for constructing complex pyrrolidine and pyrimidine-containing molecular frameworks.

Basic Information

Product Name	2-(4-Chloro-5-Methyl-Pyrimidin-2-Yloxymethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1289385-82-5
Molecular Formula	C15H22ClN3O3
Molecular Weight	327.81 g/mol
Synonyms	tert-Butyl 2-[[(4-chloro-5-methyl-2-pyrimidinyl)oxy]methyl]-1-pyrrolidinecarboxylate; 1-Pyrrolidinecarboxylic acid, 2-[[(4-chloro-5-methyl-2-pyrimidinyl)oxy]methyl]-, 1,1-dimethylethyl ester; 2-((4-Chloro-5-methylpyrimidin-2-yloxy)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester; 2-((4-Chloro-5-methylpyrimidin-2-yl)oxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester; 2-(4-Chloro-5-methyl-pyrimidin-2-yloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester; CAS 1289385-82-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles. Quality is assured through rigorous in-process controls and validated analytical methods, including HPLC, GC, and NMR, to ensure batch-to-batch consistency and compliance with client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.