Description

(1R,4R)-[4-(4-Chloro-5-Methyl-Pyrimidin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in targeted therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this material for the efficient and scalable production of advanced drug candidates, where precise molecular architecture is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug molecules.
• API Development: Used in research and process development for new active pharmaceutical ingredients, especially in oncology and antiviral fields.
• Preclinical & Clinical Trial Material Manufacturing: Essential for producing batches of investigational drugs for toxicity studies and human trials.
• Process Chemistry & Route Scouting: Employed by chemists to develop and optimize efficient, cost-effective synthetic pathways.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity due to its defined (1R,4R) stereochemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical production.

Basic Information

Product Name	(1R,4R)-[4-(4-Chloro-5-Methyl-Pyrimidin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester
CAS No.	1289385-37-0
Molecular Formula	C16H24ClN5O2
Molecular Weight	353.85 g/mol
Synonyms	(1R,4R)-N-[4-[(4-Chloro-5-methyl-2-pyrimidinyl)amino]cyclohexyl]carbamic acid 1,1-dimethylethyl ester; tert-Butyl N-[(1R,4R)-4-[(4-chloro-5-methylpyrimidin-2-yl)amino]cyclohexyl]carbamate; (1R,4R)-4-((4-Chloro-5-methylpyrimidin-2-yl)amino)cyclohexylcarbamic acid tert-butyl ester; (1R,4R)-tert-Butyl (4-((4-chloro-5-methylpyrimidin-2-yl)amino)cyclohexyl)carbamate; BOC-protected (1R,4R)-cyclohexylamine pyrimidine derivative; CAS 1289385-37-0
EINECS	Contact for details

Quality Control

Every batch of (1R,4R)-[4-(4-Chloro-5-Methyl-Pyrimidin-2-Ylamino)-Cyclohexyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis and impurity profiling, to ensure compliance with the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.