Description

1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-Azetidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic scaffold. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation drugs, leveraging its reactive sites for further functionalization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Used in research and production of protein kinase inhibitors, a major class of therapeutics for oncology and inflammatory diseases.
• Chemical Biology & Proteomics: Serves as a core scaffold for designing chemical probes to study enzyme function and protein-protein interactions.
• Agrochemical Research: Employed in the discovery and development of new herbicides and fungicides due to its bioactive pyrimidine core.
• Material Science: Potential precursor for specialty polymers or ligands in catalytic systems, exploiting its carboxylic acid functionality.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.

Basic Information

Product Name	1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-Azetidine-3-Carboxylic Acid
CAS No.	1289384-70-8
Molecular Formula	C9H10ClN3O2S
Molecular Weight	259.71 g/mol
Synonyms	1-(6-Chloro-2-(methylthio)pyrimidin-4-yl)azetidine-3-carboxylic acid; Azetidine-3-carboxylic acid, 1-(6-chloro-2-(methylthio)-4-pyrimidinyl)-; 1289384-70-8; 1-(6-Chloro-2-methylsulfanylpyrimidin-4-yl)azetidine-3-carboxylic acid; 3-Carboxy-1-(6-chloro-2-methylsulfanyl-4-pyrimidyl)azetidine
EINECS	Contact for details

Quality Control

Our production of 1-(6-Chloro-2-Methylsulfanyl-Pyrimidin-4-Yl)-Azetidine-3-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all specified parameters. We support development and commercial projects with material produced under a quality system aligned with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.