Description

2-Fluoro-6-Nitro-n-(Piperidin-4-Ylmethyl)Aniline Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1286263-43-1. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and oncological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of complex, small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique fluorinated nitroaniline and piperidine motifs.
• Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Academic Research: Employed in university and institutional labs for developing new synthetic methodologies and exploring bioorganic chemistry.
• Pre-clinical Development: Integral in the early-stage development of potential therapeutics for neurological disorders and cancer.

Basic Information

Product Name	2-Fluoro-6-Nitro-n-(Piperidin-4-Ylmethyl)Aniline Hydrochloride
CAS No.	1286263-43-1
Molecular Formula	C₁₃H₁₇FN₃O₂·HCl
Molecular Weight	299.75 g/mol (Free base: 263.29 g/mol)
Synonyms	4-[(2-Fluoro-6-nitroanilino)methyl]piperidine hydrochloride; 1-(2-Fluoro-6-nitrophenyl)-N-(piperidin-4-ylmethyl)amine hydrochloride; 2-Fluoro-6-nitro-N-(piperidin-4-ylmethyl)aniline hydrochloride; 2-Fluoro-6-nitro-N-(4-piperidylmethyl)aniline HCl; N-(2-Fluoro-6-nitrophenyl)-1-piperidinemethanamine hydrochloride; 1286263-43-1; 2-Fluoro-6-nitroaniline piperidinylmethyl derivative HCl
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Nitro-n-(Piperidin-4-Ylmethyl)Aniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.