Description

(S)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate featuring a fluorinated aromatic amine and a protected pyrrolidine moiety. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapies. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers requiring precise stereochemistry and high batch-to-batch consistency for process development and scale-up.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or warhead component in the design of targeted protein degradation molecules.
• Agrochemical Research: Serves as a precursor for advanced fluorinated compounds with potential herbicidal or insecticidal activity.
• Material Science: Intermediate for specialty polymers and advanced organic electronic materials requiring fluorinated aromatic structures.
• Academic & Contract Research: Essential reagent for medicinal chemistry programs exploring structure-activity relationships (SAR) around fluorinated heterocycles.

Basic Information

Product Name	(S)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate
CAS No.	1286207-29-1
Molecular Formula	C15H22FN3O2
Molecular Weight	295.36 g/mol
Synonyms	Carbamic acid, N-[(3S)-1-(2-amino-6-fluorophenyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; tert-Butyl ((3S)-1-(2-amino-6-fluorophenyl)pyrrolidin-3-yl)carbamate; (S)-tert-Butyl (1-(2-amino-6-fluorophenyl)pyrrolidin-3-yl)carbamate; (S)-1-(2-Amino-6-fluorophenyl)pyrrolidin-3-yl tert-butyl carbamate; (S)-Boc-protected 1-(2-amino-6-fluorophenyl)pyrrolidin-3-amine; (S)-N-Boc-1-(2-amino-6-fluorophenyl)pyrrolidin-3-amine; (S)-3-((tert-Butoxycarbonyl)amino)-1-(2-amino-6-fluorophenyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess, ensuring compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee supply reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.