Description

4,6-Dichloro-2-Morpholinopyrimidine-5-Carbaldehyde is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its reactive aldehyde and halogenated pyrimidine structure, enabling precise molecular construction for complex target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Research & Development: Serves as a versatile scaffold for constructing diverse heterocyclic libraries in medicinal chemistry and material science.
• Fine Chemical Production: Employed in the manufacture of specialty dyes, pigments, and advanced organic materials.
• Cross-Coupling Reactions: The chloro substituents make it a suitable substrate for palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig couplings.
• Nucleophilic Substitution: The morpholino and aldehyde groups provide sites for further functionalization and derivatization.

Basic Information

Product Name	4,6-Dichloro-2-Morpholinopyrimidine-5-Carbaldehyde
CAS No.	1282537-80-7
Molecular Formula	C9H9Cl2N3O2
Molecular Weight	262.09 g/mol
Synonyms	2-Morpholino-4,6-dichloropyrimidine-5-carboxaldehyde; 4,6-Dichloro-2-morpholin-4-ylpyrimidine-5-carbaldehyde; 5-Formyl-4,6-dichloro-2-morpholinopyrimidine; 4,6-Dichloro-2-(morpholin-4-yl)pyrimidine-5-carbaldehyde; 2-(Morpholin-4-yl)-4,6-dichloropyrimidine-5-carbaldehyde; 4,6-Dichloro-2-morpholin-4-yl-5-pyrimidinecarboxaldehyde; 1282537-80-7
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-2-Morpholinopyrimidine-5-Carbaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.