Description

n-Fmoc-4-(4-Chlorophenyl)-L-Phenylalanine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound matters as a critical building block for constructing complex peptide sequences with enhanced stability and specific bioactivity. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic peptides, peptidomimetics, and as a key intermediate in solid-phase peptide synthesis (SPPS). Its unique chlorophenyl side chain provides a handle for further functionalization and modulates the peptide's physicochemical properties.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Serves as a scaffold to create molecules that mimic the structure and function of natural peptides with improved metabolic stability.
• Bioconjugation and Labeling: The Fmoc-protected amine and reactive carboxyl group allow for site-specific conjugation to other molecules, tags, or solid supports.
• Chemical Biology Probes: Incorporated into peptides used as tools to study protein-protein interactions, enzyme activity, and cellular pathways.
• Academic & Institutional Research: Essential for laboratories focused on organic synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	n-Fmoc-4-(4-Chlorophenyl)-L-Phenylalanine
CAS No.	1282042-60-7
Molecular Formula	C30H24ClNO4
Molecular Weight	497.97 g/mol
Synonyms	Fmoc-4-(4-Chloro-phenyl)-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(4-chlorophenyl)-L-phenylalanine; Fmoc-Phe(4-ClPh)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4'-(4-chlorophenyl)-[1,1'-biphenyl]-4-yl)propanoic acid; N-α-Fmoc-4'-(4-chlorophenyl)-L-phenylalanine; Fmoc-L-Phe(4-Cl-Ph)-OH; Boc-L-Phe(4-Cl-Ph)-OH (common related variant)
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-(4-Chlorophenyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.