Description

n-Fmoc-4-(3-Pyridinyl)-D-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to introduce a pyridinyl-substituted phenylalanine residue with D-configuration into peptide chains, enabling the creation of novel peptide structures with enhanced stability and specific binding properties. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, especially those requiring D-amino acids for metabolic stability.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Peptidomimetic Design: The 3-pyridinyl moiety provides a heterocyclic handle for molecular interactions, useful in designing peptidomimetics with improved pharmacokinetic properties.
• Bioconjugation and Probe Development: Serves as a precursor for synthesizing labeled peptides for imaging, diagnostic assays, and targeted drug delivery systems.
• Chemical Biology Studies: Incorporated into peptides to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.

Basic Information

Product Name	n-Fmoc-4-(3-Pyridinyl)-D-Phenylalanine
CAS No.	1282042-52-7
Molecular Formula	C30H26N2O4
Molecular Weight	478.54 g/mol
Synonyms	Fmoc-D-4-(3-Pyridyl)-Phe-OH; Fmoc-4-(3-Pyridinyl)-D-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(3-pyridinyl)-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(pyridin-3-yl)phenyl)propanoic acid; D-4-(3-Pyridyl)phenylalanine Fmoc derivative; Fmoc-D-Phe(4-3-Pyridyl)-OH; Fmoc-3-(4-(3-Pyridyl)phenyl)-D-alanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-(3-Pyridinyl)-D-Phenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm the D-configuration, ensuring compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.