Description

6-tert-Butyl 4-Ethyl 2-(Methylthio)-7,8-Dihydropyrido[4,3-D]Pyrimidine-4,6(5H)-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, particularly in the development of kinase inhibitors and other targeted therapeutics. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing API manufacturing routes.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and pyrimidine derivatives.

Basic Information

Product Name	6-tert-Butyl 4-Ethyl 2-(Methylthio)-7,8-Dihydropyrido[4,3-D]Pyrimidine-4,6(5H)-Dicarboxylate
CAS No.	1279816-50-0
Molecular Formula	C20H27N3O4S
Molecular Weight	405.51 g/mol
Synonyms	6-tert-Butyl 4-ethyl 2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4,6-dicarboxylate; 2-(Methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-4,6(5H)-dicarboxylic acid 4-ethyl 6-(1,1-dimethylethyl) ester; 1279816-50-0; tert-Butyl 4-ethyl 2-methylsulfanyl-5,8-dihydro-4H-pyrido[4,3-d]pyrimidine-4,6-dicarboxylate; Ethyl 6-(tert-butoxycarbonyl)-2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 6-tert-Butyl 4-Ethyl 2-(Methylthio)-7,8-Dihydropyrido[4,3-D]Pyrimidine-4,6(5H)-Dicarboxylate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) documenting identity, purity, and impurities are provided to ensure traceability and compliance with your internal specifications and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.