Description

(2R,3R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-Methoxybutanoic Acid is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound matters as a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and molecular architecture. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid monomer for the sequential assembly of custom peptides.
• Peptidomimetic Drug Discovery: Used to introduce methoxy-substituted, non-proteinogenic amino acid motifs into lead compounds to enhance metabolic stability and binding affinity.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and enzyme mechanisms through the incorporation of modified amino acids.
• Synthesis of Bioactive Peptides: Enables the production of peptides with specific chiral configurations for pharmaceutical and biochemical applications.
• Material Science: Potential use in creating functionalized polymers and advanced biomaterials with peptide-based components.

Basic Information

Product Name	(2R,3R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-Methoxybutanoic Acid
CAS No.	1279032-75-5
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-(2R,3R)-3-Methoxy-D-β-methylphenylalanine; Fmoc-D-β-Me-3-OMe-Phe-OH; (2R,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxybutanoic acid; Fmoc-3-Methoxy-D-β-methylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-D-β-methylphenylalanine; Fmoc-D-β-methyl-3-methoxyphenylalanine; (2R,3R)-2-(Fmoc-amino)-3-methoxybutanoic acid
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-Methoxybutanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.